Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
M. A. Fischer, A.-H. M. Mustafa, K. Hausmann, R. Ashry, A. G. Kansy, M. C. Liebl, C. Brachetti, A. Piee-Staffa, M. Zessin, H. S. Ibrahim, T. G. Hofmann, M. Schutkowski, W. Sippl, O. H. Kramer
This paper synthesizes novel HDAC inhibitors that show nanomolar activity against class I HDACs and induce apoptosis while constraining autophagy in leukemic cells.
bioRxiv · Mar 9, 2023Pharmacology & Toxicology