Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
C. C. Murdoch, S. T. Espenschied, M. A. Matty, O. Mueller, D. M. Tobin, J. F. Rawls
This study identifies Serum Amyloid A (Saa) as a mediator of intestinal microbiota regulation of neutrophil function, showing it suppresses inflammation and bacterial killing while enhancing wound migration.
bioRxiv · Oct 4, 2018Immunology