Author

J. F. Rawls

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 2 Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:zebrafish· 7 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:metabolomics· 2

Frequent Co-Authors

J. Wen· 3 shared C. R. Lickwar· 2 shared J. R. McCann· 2 shared L. A. David· 2 shared L. Ye· 2 shared M.-C. Shen· 2 shared O. Mueller· 2 shared S. A. Farber· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersPhysiology

J. Wen

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation

Y. Jin, D. Kozan, J. Anderson, M. Hensley, M.-C. Shen, J. Wen, T. Moll, H. Kozan, J. F. Rawls, S. A. Farber

This study shows that a high-cholesterol diet in zebrafish leads to hypercholesterolemia and fasting-induced liver triglyceride accumulation, with lipid accumulation in adipocytes contributing to hepatic steatosis.

bioRxiv · Nov 1, 2023 · PreprintPhysiology

Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

J. H. Thierer, O. Foresti, P. K. Yadav, M. H. Wilson, T. Moll, M.-C. Shen, E. Busch-Nentwich, M. Morash, K. Mohlke, J. F. Rawls, V. Malhotra, M. M. Hussain, S. A. Farber

The paper identifies Pla2g12b as essential for lipid loading onto nascent triglyceride-rich lipoproteins, showing its role in TRL expansion and its impact on atherosclerosis resistance.

bioRxiv · Aug 2, 2022 · PreprintCell Biology

Transcriptomics informs design of a planar human enterocyte culture system that reveals metformin enhances fatty acid export

I. Gomez-Martinez, R. J. Bliton, K. A. Breau, M. J. Czerwinski, I. A. Williamson, J. Wen, J. F. Rawls, S. T. Magness

The paper develops a human enterocyte culture system to study lipid handling and finds metformin enhances fatty acid export by promoting fatty acid oxidation.

bioRxiv · Jan 24, 2022 · PreprintCell Biology

The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice

W. Tong, S. A. Hannou, Y. Wang, I. Astapova, A. Sargsyan, R. Monn, V. Thiriveedi, D. Li, J. R. McCann, J. F. Rawls, J. Roper, G.-F. Zhang, M. A. Herman

This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.

bioRxiv · Jan 20, 2022Physiology

Tributyltin exposure leads to increased adiposity and reduced abundance of leptogenic bacteria in the zebrafish intestine

S. Gomez de la Torre Canny, O. Mueller, C. V. Craciunescu, B. Blumberg, J. F. Rawls

This study shows tributyltin increases adiposity in zebrafish by reducing leptogenic Plesiomonas bacteria in the intestine.

bioRxiv · Jul 9, 2021 · PreprintMicrobiology

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

J. Wen, G. Padilla Mercado, A. Volland, H. L. Doden, C. R. Lickwar, T. Crooks, G. Kakiyama, C. Kelly, J. L. Cocchiaro, J. M. Ridlon, J. F. Rawls

This study investigates Fxr signaling and microbial bile salt metabolism in zebrafish intestines, revealing conserved pathways and Fxr roles in transcriptional programs.

bioRxiv · Dec 13, 2020Physiology

Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice

Z. C. Holmes, J. D. Silverman, H. K. Dressman, Z. Wei, E. P. Dallow, S. C. Armstrong, P. C. Seed, J. F. Rawls, L. A. David

This study examines SCFA production by gut microbiota from children with obesity in response to different prebiotics, finding significant inter-donor variation and donor-dependent effectiveness.

mBio · Aug 25, 2020Peer-reviewedMicrobiology

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

L. Ye, M. Bae, C. D. Cassilly, S. V. Jabba, D. W. Thorpe, A. M. Martin, H.-Y. Lu, J. Wang, J. D. Thompson, C. R. Lickwar, K. D. Poss, D. J. Keating, S.-E. Jordt, J. Clardy, R. A. Liddle, J. F. Rawls

This study identifies a molecular pathway by which enteroendocrine cells respond to bacterial tryptophan catabolites, activating enteric and vagal neurons through Trpa1 signaling.

bioRxiv · Jun 9, 2020Physiology

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish

P. M. Cholan, A. Han, B. R. Woodie, A. R. Kurz, W. J. Britton, L. Ye, Z. C. Holmes, J. R. McCann, L. A. David, J. F. Rawls, S. H. Oehlers

The paper shows that butyrate, a short-chain fatty acid, has anti-inflammatory effects in zebrafish by reducing neutrophil and M1 macrophage recruitment to wounds, and identifies a conserved receptor for butyrate sensing in fish.

bioRxiv · May 13, 2020Immunology

Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization

C. C. Murdoch, S. T. Espenschied, M. A. Matty, O. Mueller, D. M. Tobin, J. F. Rawls

This study identifies Serum Amyloid A (Saa) as a mediator of intestinal microbiota regulation of neutrophil function, showing it suppresses inflammation and bacterial killing while enhancing wound migration.

bioRxiv · Oct 4, 2018Immunology