Author

D. M. Tobin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:zebrafish· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. R. Menon· 2 shared K. R. Nicholson· 2 shared M. K. Jennisch· 2 shared P. A. Champion· 2 shared R. M. Cronin· 2 shared S. H. Oehlers· 2 shared A. J. Pagan· 1 shared C. B. Moens· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

A. R. Menon

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

K. R. Nicholson, R. M. Cronin, R. J. Prest, A. R. Menon, Y. Yang, M. K. Jennisch, M. Champion, D. M. Tobin, P. A. Champion

This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.

bioRxiv · Jan 9, 2024Microbiology

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in M. marinum

K. R. Nicholson, R. M. Cronin, A. R. Menon, M. K. Jennisch, D. M. Tobin, P. A. Champion

This study identifies EspN as an infection-dependent transcription factor that regulates ESX-1 gene expression during mycobacterial infection, but not under standard lab conditions.

bioRxiv · Feb 15, 2023 · PreprintMicrobiology

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

A. J. Pagan, L. J. Lee, J. Edwards-Hicks, C. B. Moens, D. M. Tobin, E. M. Busch-Nentwich, E. L. Pearce, L. Ramakrishnan

This study identifies mTOR as a host factor that protects macrophages from Mycobacterium-induced death by regulating mitochondrial metabolism.

Cell · Sep 1, 2022Peer-reviewedImmunology

Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish

J. Y. Kam, T. Cheng, D. C. Garland, W. J. J. Britton, D. M. Tobin, S. H. Oehlers

The paper shows that inhibiting vascular permeability in zebrafish reduces granuloma hypoxia and shifts immune cell recruitment from neutrophils to T cells, improving mycobacterial infection outcomes.

bioRxiv · Nov 23, 2021Immunology

Thrombocyte inhibition restores protective immunity to mycobacterial infection

E. Hortle, K. E. Johnson, M. D. Johansen, T. Nguyen, J. A. Shavit, W. J. Britton, D. M. Tobin, S. H. Oehlers

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

bioRxiv · Dec 1, 2018Immunology

Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization

C. C. Murdoch, S. T. Espenschied, M. A. Matty, O. Mueller, D. M. Tobin, J. F. Rawls

This study identifies Serum Amyloid A (Saa) as a mediator of intestinal microbiota regulation of neutrophil function, showing it suppresses inflammation and bacterial killing while enhancing wound migration.

bioRxiv · Oct 4, 2018Immunology