Unravelling the Graded Millisecond Allosteric Activation Mechanism of Imidazole Glycerol Phosphate Synthase
C. Calvo-Tusell, M. A. Maria-Solano, S. Osuna, F. Feixas
This paper uses computational methods to simulate the millisecond timescale allosteric activation mechanism of IGPS, revealing how effector binding lowers conformational barriers and enhances catalytic activity.
bioRxiv · Oct 21, 2021 · PreprintBiophysics