Author

T. J. Erb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 4 Organism:bacteria (other)· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Bar-Even· 2 shared A. Gomez· 2 shared G. M. M. Stoffel· 2 shared H. Demirci· 2 shared J. Zarzycki· 2 shared L. Calzadiaz Ramirez· 2 shared L. Schulz· 2 shared N. Paczia· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

A. Bar-Even

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Author profile →

8 papers

Recent·Most cited

Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans

L. Schada von Borzyskowski, L. Hermann, K. Kremer, S. Barthel, B. Pommerenke, T. Glatter, N. Paczia, E. Bremer, T. J. Erb

This study identifies multiple transcriptional regulators controlling glycolate metabolism in Paracoccus denitrificans, revealing a complex regulatory network for carbon assimilation.

bioRxiv · Mar 11, 2024 · PreprintMicrobiology

Layered entrenchment maintains essentiality in protein-protein interactions.

L. Schulz, J. Zarzycki, W. Steinchen, G. K. A. Hochberg, T. J. Erb

The paper shows that multiple mechanisms of essentiality in protein-protein interactions can persist over time, even if individual mechanisms are lost, using Rubisco as a case study.

bioRxiv · Jan 18, 2024 · PreprintBiochemistry

Structural Insights into the Iron Nitrogenase Complex

F. V. Schmidt, L. Schulz, J. Zarzycki, N. N. Oehlmann, S. Prinz, T. J. Erb, J. G. Rebelein

The paper reports the cryogenic electron microscopy structure of the Fe nitrogenase complex from Rhodobacter capsulatus, revealing its active site architecture and subunit interactions.

bioRxiv · May 2, 2023Biochemistry

Ketosynthase engineering enhances activity and shifts specificity towards non-native extender units in type I linear polyketide synthase

P. D. Gerlinger, G. Angelidou, N. Paczia, T. J. Erb

This study engineers the ketosynthase domain of a polyketide synthase to enhance activity and shift specificity towards non-native extender units in vitro.

bioRxiv · Feb 16, 2023 · PreprintBiochemistry

Inter-subunit coupling enables fast CO2-fixation by reductive carboxylases

H. Demirci, Y. Rao, G. M. Stoffel, B. Vögeli, K. Schell, A. Gomez, A. Batyuk, C. Gati, R. G. Sierra, M. S. Hunter, E. H. Dao, H. I. Ciftci, B. Hayes, F. Poitevin, P. Li, , S. Wakatsuki

This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.

bioRxiv · Feb 23, 2022 · PreprintBiophysics

Emergence of NADP+-reducing enzymes in Escherichia coli central metabolism via adaptive evolution

M. Bouzon, V. Döring, I. Dubois, A. Berger, G. M. M. Stoffel, L. Calzadiaz Ramirez, S. Meyer, M. Foure, D. Roche, A. Perret, T. J. Erb, A. Bar-Even, S. N. Lindner

This study shows that adaptive evolution in E. coli can change cofactor specificity of enzymes, enabling NADPH regeneration without external sources, but is limited by thermodynamic constraints.

bioRxiv · Feb 8, 2021 · PreprintMicrobiology

In vivo selection for formate dehydrogenases with high efficiency and specificity towards NADP+

L. Calzadiaz Ramirez, C. Calvo-Tusell, G. M. M. Stoffel, S. Lindner, S. Osuna, T. J. Erb, M. Garcia-Borras, A. Bar-Even, C. G. Acevedo-Rocha

This study uses in vivo selection to engineer formate dehydrogenases with high efficiency and specificity for NADP+ regeneration.

bioRxiv · Apr 2, 2020 · PreprintBiochemistry

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

H. DeMirci, B. Tolar, T. Doukov, A. Petriceks, A. Pal, Y. Yoshikuni, A. Gomez, D. A. Saez, E. Vohringer-Martinez, T. Schwander, T. J. Erb, C. A. Francis, S. Wakatsuki

The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.

bioRxiv · Feb 5, 2020 · PreprintEvolutionary Biology