Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures.
J. D. Mortison, M. Schenone, J. A. Myers, Z. Zhang, L. Chen, C. Ciarlo, E. Comer, S. K. Natchiar, S. A. Carr, B. P. Klaholz, A. G. Myers
This study identifies tetracyclines as targeting human rRNA substructures, modifying translation and activating the ISR, which correlates with their anti-proliferative effects in cancer cells.
bioRxiv · Feb 1, 2018Cell Biology