PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes
C. Coulson-Gilmer, R. Morgan, L. Nelson, B. Barnes, J. McGrail, S. Taylor
This study shows that PARG inhibition causes replication catastrophe in some ovarian cancer cells with down-regulated DNA replication genes, suggesting a potential biomarker for PARG inhibitor response.
bioRxiv · Jul 13, 2020 · PreprintCancer Biology