Author

J. McGrail

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Tighe· 2 shared B. Barnes· 2 shared L. Nelson· 2 shared R. Morgan· 2 shared S. S. Taylor· 2 shared C. Coulson-Gilmer· 1 shared D. Perera· 1 shared D. Procter· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Tighe

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Author profile →

3 papers

Recent·Most cited

Classification of ovarian cancer cell lines using transcriptional profiles defines the five major pathological subtypes

B. Barnes, L. Nelson, A. Tighe, R. Morgan, J. McGrail, S. S. Taylor

This paper classifies ovarian cancer cell lines into five subtypes using transcriptional profiles, aligning with known pathological subtypes and providing a method for future classification.

bioRxiv · Jul 14, 2020 · PreprintCancer Biology

PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes

C. Coulson-Gilmer, R. Morgan, L. Nelson, B. Barnes, J. McGrail, S. Taylor

This study shows that PARG inhibition causes replication catastrophe in some ovarian cancer cells with down-regulated DNA replication genes, suggesting a potential biomarker for PARG inhibitor response.

bioRxiv · Jul 13, 2020 · PreprintCancer Biology

Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

I. Amalina, H. Whalley, D. Perera, J. McGrail, A. Tighe, D. Procter, S. S. Taylor

This study compares two Bub1 kinase inhibitors, finding that BAY-320 inhibits Bub1 in vivo but with high concentrations and potential off-target effects, while 2OH-BNPP1 is ineffective.

bioRxiv · Jul 2, 2020Cell Biology