Vaccine antigen, Factor H binding protein, is typically a non-lipidated precursor that localises to the meningococcal surface by Slam.
R. Anderson Goncalves da Silva, A. V. Karlyshev, N. J. Oldfield, K. G. Wooldridge, C. D. Bayliss, A. Ryan, R. Griffin
The paper shows that a non-lipidated precursor of Factor H binding protein is surface-localized by Slam in meningococcal isolates, challenging the assumption of lipidation for all isolates.
bioRxiv · Jul 8, 2019 · PreprintMicrobiology