Author

C. D. Lorenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. J. Mason· 3 shared D. A. Phoenix· 3 shared G. Manzo· 3 shared P. M. Ferguson· 3 shared P. Smith· 3 shared A. F. Drake· 2 shared M. Clifford· 2 shared R. A. Atkinson· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiophysics

A. J. Mason

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Temporin B forms hetero-oligomers with Temporin L, modifies its membrane activity and increases the cooperativity of its antibacterial pharmacodynamic profile

P. M. Ferguson, M. Clarke, G. Manzo, C. K. Hind, M. Clifford, J. M. Sutton, C. D. Lorenz, D. A. Phoenix, A. J. Mason

This study shows that temporin B enhances the antibacterial cooperativity of temporin L by forming hetero-oligomers, altering membrane interaction and increasing efficacy against EMRSA-15.

bioRxiv · Mar 9, 2022Biochemistry

Cholesterol Oxidation Modulates the Formation of Liquid-Ordered Domains in Model Membranes

P. Smith, P. G. Petrov, C. D. Lorenz

This paper shows that 7-ketocholesterol disrupts liquid-liquid phase separation in model membranes through two mechanisms, providing a molecular explanation for its role in apoptosis.

bioRxiv · May 24, 2021 · PreprintBiophysics

LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations

P. Smith, C. D. Lorenz

LiPyphilic is a Python toolkit for analyzing lipid membrane simulations, offering tools for cholesterol flip-flop events, lipid environment classification, and trajectory transformations.

bioRxiv · May 4, 2021Biophysics

Asymmetric phospholipids impart novel biophysical properties to lipid bilayers allowing environmental adaptation

P. Smith, D. M. Owen, C. D. Lorenz, M. Makarova

This study shows that asymmetric phospholipids in yeast membranes maintain lipid order across a wider temperature range without needing unsaturated tails or sterols.

bioRxiv · Jun 3, 2020 · PreprintBiophysics

ILC1-derived TGFβ1 drives intestinal remodelling

G. M. Jowett, M. D. A. Norman, T. T. L. Yu, P. Rosell Arevalo, D. Hoogland, S. Lust, E. Read, E. Hamrud, N. J. Walters, U. Niazi, M. W. H. Chung, D. Marciano, O. S. Omer, T. Zabinski, D. Danovi, , E. Gentleman

The paper shows ILC1-derived TGFβ1 drives intestinal epithelial crypt expansion and extracellular matrix remodeling in co-cultured organoids.

bioRxiv · Apr 20, 2020Immunology

Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

G. Manzo, P. M. Ferguson, V. B. Gustilo, T. T. Bui, A. F. Drake, R. A. Atkinson, G. Batoni, C. D. Lorenz, D. A. Phoenix, A. J. Mason

The paper investigates how minor sequence changes in temporin B affect its antibacterial potency and selectivity by altering its membrane interaction mechanisms.

bioRxiv · Aug 9, 2018Biophysics

Parallel evolution of frog antimicrobial peptides produces identical conformations but subtly distinct membrane and antibacterial activities

G. Manzo, P. M. Ferguson, C. Hind, M. Clifford, V. B. Gustilo, H. Ali, S. S. Bansal, T. T. Bui, A. F. Drake, R. A. Atkinson, M. J. Sutton, C. D. Lorenz, D. A. Phoenix, A. J. Mason

This study compares two frog antimicrobial peptides, temporin L and aurein 2.5, to understand their differing antibacterial activities despite similar structures.

bioRxiv · Aug 9, 2018Biophysics