Author

D. Danovi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

E. Gentleman· 2 shared E. Roy· 2 shared L. Veschini· 2 shared M. Battilocchi· 2 shared A. Kuziola· 1 shared A. M. Syanda· 1 shared A. Pellon· 1 shared C. A. Dreiss· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

E. Gentleman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Morphogen-driven human iPSCs differentiation in 3D in vitro models of gastrulation is precluded by physical confinement.

H. S. Alsehli, E. Roy, T. Williams, A. Kuziola, Y. Guo, J. B. Green, E. Gentleman, D. Danovi

This study shows that physical confinement reduces SOX17 expression in hiPSCs spheroids during gastrulation, but time-softening hydrogels rescue this effect.

bioRxiv · Mar 29, 2023 · PreprintCell Biology

A spatialised agent-based model of NOTCH signalling pathway in Endothelial Cells predicts emergent heterogeneity due to continual dynamic phenotypic adjustments.

F. Chesnais, T. J. Sego, E. Engstler, M. Battilocchi, D. Danovi, J. A. Glazier, L. Veschini

The paper uses a spatialised agent-based model to show NOTCH signalling pathway dynamics in endothelial cells can generate spatial heterogeneity through oscillations and phenotypic adjustments.

bioRxiv · Aug 6, 2022 · PreprintCell Biology

Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency

D. Kent, S. S. Ng, P. Khoshkenar, A. M. Syanda, L. Chao Zheng, M. Zieger, C. Greer, S. B. Hatch, J. M. Segal, S. J. I. Blackford, V. Chowdary, T. Ismali, D. Danovi, S. Sahdeo, D. Ebner, , S. T. Rashid

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

bioRxiv · Sep 17, 2021 · PreprintCell Biology

High content Image Analysis to study phenotypic heterogeneity in endothelial cell monolayers

F. L. Chesnais, J. Hue, E. Roy, M. Branco, R. Stokes, A. Pellon, J. Le Caillec, E. Elbahtety, M. Battilocchi, D. Danovi, L. Veschini

The paper develops an image-based tool to quantify endothelial cell heterogeneity in monolayers and identifies NOTCH signaling variation across different cell states.

bioRxiv · Nov 17, 2020Cell Biology

ILC1-derived TGFβ1 drives intestinal remodelling

G. M. Jowett, M. D. A. Norman, T. T. L. Yu, P. Rosell Arevalo, D. Hoogland, S. Lust, E. Read, E. Hamrud, N. J. Walters, U. Niazi, M. W. H. Chung, D. Marciano, O. S. Omer, T. Zabinski, D. Danovi, , E. Gentleman

The paper shows ILC1-derived TGFβ1 drives intestinal epithelial crypt expansion and extracellular matrix remodeling in co-cultured organoids.

bioRxiv · Apr 20, 2020Immunology