Steroid-resistant nephrotic syndrome associated MYO1E mutations have differential effects on myosin 1e localization, dynamics, and activity
P.-J. Liu, L. K. Gunther, D. Perez, J. Bi-Karchin, C. D. Pellenz, S. E. Chase, M. F. Presti, E. L. Plante, C. E. Martin, S. Lovric, C. M. Yengo, F. Hildebrandt, M. Krendel
This study investigates two MYO1E mutations in SRNS patients, showing T119I affects Myo1e localization and D388H reduces ATPase activity and actin translocation.
bioRxiv · Nov 11, 2021Cell Biology