Author

C. M. Yengo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 6 Approach:experimental assay· 5 Assay:proteomics· 2 Research Focus:synaptic & neural circuits· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. V. Rasicci· 3 shared R. Desetty· 3 shared J. Ge· 2 shared S. Sivaramakrishnan· 2 shared W. Tang· 2 shared A. M. Touma· 1 shared A. Rai· 1 shared C. D. Pellenz· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

D. V. Rasicci

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

S. M. Bodt, J. Ge, W. Ma, D. V. Rasicci, R. Desetty, J. A. McCammon, C. M. Yengo

This paper investigates how the E525K mutation in beta-cardiac myosin affects actin activation, power stroke, and phosphate release, revealing structural and kinetic changes linked to dilated cardiomyopathy.

PNAS Nexus · Jul 16, 2024Peer-reviewedBiophysics

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

M. H. Doran, M. J. Rynkiewicz, D. Rasicci, S. M. L. Bodt, M. E. Barry, E. Bullitt, C. M. Yengo, J. R. Moore, W. Lehman

The paper uses cryo-EM to determine high-resolution structures of human cardiac myosin bound to actin-tropomyosin in the presence and absence of Mg2+·ADP, revealing conformational changes linked to ADP release and force-sensitivity.

bioRxiv · Sep 23, 2022Biophysics

Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay

A. M. Touma, W. Tang, D. V. Rasicci, D. Vang, A. Rai, S. B. Previs, D. M. Warshaw, C. M. Yengo, S. Sivaramakrishnan

This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.

bioRxiv · Mar 11, 2022 · PreprintBiophysics

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

D. V. Rasicci, P. Tiwari, R. Desetty, F. R. Sadler, S. Sivaramakrishnan, R. Craig, C. M. Yengo

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

bioRxiv · Feb 18, 2022 · PreprintBiophysics

Steroid-resistant nephrotic syndrome associated MYO1E mutations have differential effects on myosin 1e localization, dynamics, and activity

P.-J. Liu, L. K. Gunther, D. Perez, J. Bi-Karchin, C. D. Pellenz, S. E. Chase, M. F. Presti, E. L. Plante, C. E. Martin, S. Lovric, C. M. Yengo, F. Hildebrandt, M. Krendel

This study investigates two MYO1E mutations in SRNS patients, showing T119I affects Myo1e localization and D388H reduces ATPase activity and actin translocation.

bioRxiv · Nov 11, 2021Cell Biology

Cardiomyopathy Mutations Impact the Power Stroke of Human Cardiac Myosin

W. Tang, J. Ge, W. C. Unrath, R. Desetty, C. M. Yengo

This study investigates how cardiomyopathy mutations affect the power stroke of human cardiac myosin using FRET and kinetic measurements, revealing impaired structural changes and reduced force development.

bioRxiv · Dec 8, 2020Biophysics