Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).
Cesar I. Cyuzuzo, Monica Kruk, Qi Zhang, Duha Alshareef, James Harmon, Yuichi Machida, Harrison W. VanKoten, Swati S. More, C. E. Campbell, Natalia Y. Tretyakova
This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.
bioRxiv · Mar 13, 2026 · PreprintBiochemistry