Swati S. More

Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).

This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.

Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue

This study identifies the N-terminal catalytic domain of ACE as the primary site for endogenous opioid peptide degradation in brain tissue and shows that inhibiting this domain reduces opioid degradation.

Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling

The paper identifies ACE inhibitors that enhance endogenous opioid signaling by reducing enkephalin degradation, showing analgesic effects in vivo.

Loss of the systemic vitamin A transporter RBPR2 affects the quantitative balance between chromophore and opsins in visual pigment synthesis

This study shows that loss of RBPR2 affects retinoid homeostasis and visual pigment synthesis, leading to visual function defects in mice under vitamin A deficiency.

Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice

This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Angiotensin-converting enzyme governs endogenous opioid signaling and synaptic plasticity in nucleus accumbens

This study shows that ACE inhibition enhances endogenous opioid signaling and reduces fentanyl-induced conditioned place preference in mice.