Qi Zhang

Small brown planthopper infestation enhances it reproduction and insecticide tolerance by manipulating glucose distribution and levels in rice

This paper shows how small brown planthopper infestation increases rice glucose levels, which enhances the insect's reproduction and insecticide tolerance through specific molecular pathways.

ECC-MR: an error-correcting-code framework for robust Mendelian randomization and pleiotropy decoding on correlated instruments

ECC-MR improves Mendelian randomization by using error-correcting code principles to handle pleiotropy and linkage disequilibrium, providing more accurate causal estimates.

Glutamine-regulated VCP acetylation creates a proteostasis vulnerability in RB1-deficient tumor

This study identifies VCP inhibition as a therapeutic strategy for RB1-deficient tumors by revealing glutamine-regulated VCP acetylation as a proteostasis vulnerability.

Lysosomal Dysfunction-Mediated IgG Accumulation Promotes Endothelial Senescence and Lesion Progression in Cerebral Cavernous Malformations

Glutamatergic Neuron-Meningioma Synapse Interaction Promotes Brain-Invasive Tumor Growth

The paper identifies functional glutamatergic synapses between meningioma cells and neurons, showing they promote tumor invasion and proliferation.

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcoma

This study shows that extracellular vesicles from dedifferentiated liposarcoma suppress macrophage STING signaling, leading to immune dysfunction and poor response to immunotherapy.

(2R,6R)-Hydroxynorketamine elicits rapid antidepressant effects by promoting astrocytic μ-δ opioid receptor heterodimerization

This study identifies HNK's mechanism of action through astrocytic μ-δ opioid receptor heterodimerization, showing it restores these heterodimers and produces rapid antidepressant effects.

The enhanced multi-tissue atlas of regulatory effects in cattle

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).

This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.

Absolute hand determination of glycofibrils from natural sources in cryo-EM

This study introduces Ahaha, a method for determining absolute hand of glycofibrils in cryo-EM, enabling atomic model building from natural sources.

Isolation and Characterisation of Hair Follicle-Derived Melanocytes

This study characterizes hair follicle and epidermal melanocytes, showing hair follicle melanocytes survive and proliferate after UVB irradiation, while epidermal melanocytes die, and links these findings to vitiligo treatment.

Hierarchical Assembly of Native Cytoplasmic Lattices Revealed by Cryo-EM

The paper uses cryo-EM to reveal the high-resolution structure of mouse oocyte cytoplasmic lattices, identifying their components and hierarchical assembly mechanism.

Impact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolites Composition

This study examines the effects of oral Chlamydia vaccination on gut microbiome and metabolite composition, identifying microbial and metabolic changes and potential biomarkers of immunization.

Insights into Intestinal Barrier Disruption During Long-Term Gut Chlamydia Colonization in Mice: A Single-Cell Transcriptomic Approach

This study uses single-cell RNA sequencing to investigate how Chlamydia persists in the gut of mice, revealing disruptions in epithelial tight junctions and immune-cell interactions.

Unsupervised multi-animal tracking for quantitative ethology

This paper introduces an unsupervised deep-learning method for multi-animal tracking that performs well in challenging conditions without requiring human annotations.

Variation of female pronucleus reveal oocyte or embryo abnormality: An expert experience deep learning of non-dark box analysis

The paper develops a deep learning method to quantify pronuclear (PN) features in embryos and links PN area to chromosomal abnormalities using clinical data.

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid -induced seizures in neuronal GPI anchor deficiency mouse models

This study generates PIGA-deficient mouse models to investigate the role of GPI anchor deficiency in neurological phenotypes and seizure susceptibility.

Quantification of Enterohemorrhagic Escherichia coli O157:H7 proteome using TMT-Based Analysis

This paper quantifies the proteome of EHEC O157:H7 using TMT-based analysis, identifying 2,234 proteins and highlighting key pathways and abundant proteins involved in physiology and pathogenesis.

Cullin1 represses systematic inflammasome activation by binding and catalyzing NLRP3 ubiquitination

This study identifies CUL1 as a repressor of NLRP3 inflammasome activation by ubiquitinating NLRP3, showing its role in controlling immune responses under physiological and inflammatory conditions.

A high-throughput analysis method of microdroplet PCR coupled with fluorescence spectrophotometry

This paper introduces a microdroplet PCR method combined with fluorescence spectrophotometry for qualitative, quantitative, and high-throughput DNA detection, validated using GM maize and foodborne bacteria.

MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGS

The paper investigates the role of Ntng gene paralogs in mouse executive function, showing differential expression in brain regions and task-dependent modulation of cognitive processes.

COGNITIVE DOMAINS FUNCTION COMPLEMENTATION BY NTNG GENE PARALOGS

The paper investigates how NTNG1 and NTNG2 paralogs functionally complement each other in cognitive domains and contribute to neurocognitive disorders through subfunctionalization.

COGNITIVE ENDOPHENOTYPES OF MODERN AND EXTINCT HOMININS ASSOCIATED WITH NTNG GENE PARALOGS

The paper identifies cognitive endophenotypes linked to NTNG gene paralogs in humans and extinct hominins, showing evolutionary changes and associations with IQ traits.