IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma
S. Medina, A. A. Brockman, C. E. Cross, M. J. Hayes, B. C. Mobley, A. M. Mistry, S. Chotai, K. D. Weaver, R. Thompson, L. B. Chambless, R. A. Ihrie, J. M. Irish
This study identifies IL-8 as a key factor instructing macrophage identity in glioblastoma, showing IL-8 is necessary for generating CD32+ M_IL-8 macrophages in tumors contacting the lateral ventricle.
bioRxiv · Mar 29, 2024 · PreprintCancer Biology