Author

R. A. Ihrie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Research Focus:clustering· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. M. Mistry· 3 shared B. C. Mobley· 3 shared J. M. Irish· 3 shared K. D. Weaver· 3 shared L. B. Chambless· 3 shared A. A. Brockman· 2 shared J. Sinnaeve· 2 shared M. J. Hayes· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

A. M. Mistry

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma

S. Medina, A. A. Brockman, C. E. Cross, M. J. Hayes, B. C. Mobley, A. M. Mistry, S. Chotai, K. D. Weaver, R. Thompson, L. B. Chambless, R. A. Ihrie, J. M. Irish

This study identifies IL-8 as a key factor instructing macrophage identity in glioblastoma, showing IL-8 is necessary for generating CD32+ M_IL-8 macrophages in tumors contacting the lateral ventricle.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

S. A. Ajaib, D. Lodha, S. Pollock, G. Hemmings, M. Finetti, A. Gusnanto, A. Chakrabarty, A. Ismail, E. Wilson, F. S. Varn, B. Hunter, A. Filby, A. A. Brockman, D. McDonald, R. Verhaak, , L. F. Stead

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

Neuro-Oncology · Jul 6, 2023Peer-reviewedCancer Biology

Non-Canonical Functions of a Mutant TSC2 Protein in Mitotic Division

M.-B. L. Chalkley, R. B. Mersfelder, M. Sundberg, L. Armstrong, M. Sahin, R. A. Ihrie, K. Ess

This study identifies a novel mTORC1-independent multipolar mitotic division phenotype in TSC2 mutant iPSCs, suggesting non-canonical functions of mutant TSC2.

bioRxiv · Dec 7, 2022 · PreprintCell Biology

Immune cell regulation in stem cell niche contacting glioblastomas.

T. Bartkowiak, S. M. Lima, M. J. Hayes, A. M. Mistry, J. Sinnaeve, N. Leelatian, C. E. Roe, B. C. Mobley, K. D. Weaver, R. C. Thompson, L. B. Chambless, R. A. Ihrie, J. M. Irish

This study shows that glioblastomas contacting the lateral ventricle have distinct immune features, including elevated T cell checkpoint receptors and suppressive myeloid cells, suggesting new therapeutic targets.

bioRxiv · Feb 16, 2022 · PreprintImmunology

High risk glioblastoma cells revealed by machine learning and single cell signaling profiles

N. Leelatian, J. Sinnaeve, A. M. Mistry, S. M. Barone, K. E. Diggins, A. R. Greenplate, K. D. Weaver, R. C. Thompson, L. B. Chambless, B. C. Mobley, R. A. Ihrie, J. M. Irish

This paper introduces RAPID, an unsupervised machine learning algorithm that identifies single cell phenotypes and assesses clinical risk stratification in glioblastoma patients using single cell mass cytometry data.

bioRxiv · Jun 1, 2019Cancer Biology