Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches
H. A. Nguyen, C. E. Fagan, E. D. Hoffer, T. Maehigashi, C. M. Dunham
The paper presents crystal structures showing how a P-site codon-anticodon mismatch reduces A-site fidelity, allowing for quality control of protein synthesis.
bioRxiv · Jan 28, 2023Biochemistry