Author

H. A. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:electrophysiology· 1

Frequent Co-Authors

C. M. Dunham· 3 shared A. B. Kuzmishin Nagy· 1 shared A. Caldwell· 1 shared C. A. Wu· 1 shared C. E. Fagan· 1 shared D. Dey· 1 shared D. Jilani· 1 shared E. D. Hoffer· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

C. M. Dunham

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

N. Marathe, H. A. Nguyen, J. N. Alumasa, A. B. Kuzmishin Nagy, M. Y. Vazquez, C. M. Dunham, K. C. Keiler

This paper identifies KKL-55, a tetrazole-based antibiotic that specifically inhibits EF-Tu binding to tmRNA without affecting tRNA binding, suggesting a new target for antibiotic development.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

Consecutive treatments of methamphetamine promote the 4 development of cardiac pathological symptoms in zebrafish

J. Zhang, H. A. Nguyen, D. Jilani, R. S. T. Torres, L. Schmiess-Heine, T. N. Le, X. Xia, H. Cao

This study investigates the effects of repeated methamphetamine exposure on zebrafish cardiac function, revealing decreased heart rate, increased heart rate variability, and fibrotic changes.

bioRxiv · May 28, 2023Physiology

Analyzing genomic alterations involved in fluoroquinolone-resistant development in Staphylococcus aureus

T. Q. Huynh, V. N. Tran, V. C. Thai, H. A. Nguyen, N. T. G. Nguyen, N. U. Surian, S. Chen, T. T. H. Nguyen

This study investigates genomic and gene expression changes in Staphylococcus aureus after fluoroquinolone exposure, identifying mutations and overexpressed genes linked to multidrug resistance.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches

H. A. Nguyen, C. E. Fagan, E. D. Hoffer, T. Maehigashi, C. M. Dunham

The paper presents crystal structures showing how a P-site codon-anticodon mismatch reduces A-site fidelity, allowing for quality control of protein synthesis.

bioRxiv · Jan 28, 2023Biochemistry

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Z. T. Laughlin, S. Nandi, D. Dey, N. Zelinskaya, M. A. Witek, P. Srinivas, H. A. Nguyen, E. G. Kuiper, L. R. Comstock, C. M. Dunham, G. L. Conn

This paper reports the structure of the Mycobacterium tuberculosis TlyA enzyme bound to the 50S ribosomal subunit, revealing mechanisms of rRNA substrate recognition and modification that contribute to antibiotic resistance.

bioRxiv · Nov 11, 2021Biochemistry

Convergence of glandular trichome morphology and chemistry in two montane monkeyflower species

S. Bustamante Eguiguren, H. A. Nguyen, A. Caldwell, K. A. Nolin, C. A. Wu

This study compares glandular trichome morphology and chemistry in two distantly related monkeyflower species, finding similar features suggesting convergent adaptation to environmental conditions.

bioRxiv · Nov 5, 2019Plant Biology