Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques
A. Verma, C. E. Hawes, S. R. Elizaldi, J. C. Smith, D. Rajasundaram, G. K. Pedersen, X. Shen, L. D. Williams, G. D. Tomaras, P. A. Kozlowski, R. R. Amara, S. S. Iyer
This study shows that inducing GC Tfh1 cells with MPLA+QS-21 adjuvant leads to higher and longer-lasting HIV-1 Env antibodies in rhesus macaques compared to CAF01.
bioRxiv · Jul 18, 2023 · PreprintImmunology