S. S. Iyer

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and Susceptibility imaging

This paper introduces sEPTI, a 3D imaging technique for rapid whole-brain T2* and susceptibility mapping, achieving faster imaging and improved quality compared to existing methods.

Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques

This study shows that inducing GC Tfh1 cells with MPLA+QS-21 adjuvant leads to higher and longer-lasting HIV-1 Env antibodies in rhesus macaques compared to CAF01.

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

Selective targeting of α4β7/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

This study shows that targeting the α4β7/MAdCAM-1 axis reduces proinflammatory T cell recruitment to the liver, thereby suppressing liver fibrosis progression in a mouse model.

Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques

This study identifies inducible bronchus-associated lymphoid tissue in SARS-CoV-2 infected rhesus macaques, suggesting local immunity plays a role in infection.

Distinct upper airway epithelium interferon-stimulated and profibrotic gene expression between adult and infant rhesus macaques infected with SARS-CoV-2

This study compares SARS-CoV-2 infection effects in adult and infant rhesus macaques, finding distinct interferon-stimulated and profibrotic gene expression patterns in upper airway epithelium.

Enthalpic and Entropic Contributions to Interleaflet Coupling Drive Domain Registration and Anti-registration in Biological Membrane

The paper develops an analytical theory to explain domain registration and anti-registration in biological membranes by analyzing enthalpic and entropic contributions to interleaflet coupling.

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

Hydrophobic residues advance the onset of simple coacervation in intrinsically disordered proteins at low densities: Insights from field theoretical simulations studies

This study extends field theoretical simulations to show that hydrophobic residues lower the onset density for coacervation in IDPs, highlighting their role in phase separation.

Interpretation of Phase Boundary Fluctuation Spectra in Biological Membranes with Nanoscale Organization

This paper uses SVM to analyze molecular simulations of lipid bilayers, showing how interface detection and fluctuation spectra depend on resolution and geometry.

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

Intrinsic Disorder and Degeneracy in Molecular Scale Organization of Biological Membrane

This study investigates the energy landscape of lipid bilayers, finding that in-vivo systems exhibit frustrated landscapes enabling diverse nanoscale patterns compared to in-vitro systems.

Characterizing the Liquid-liquid Phase Co-existence in Biomembrane: Insights from Local Non-affine Deformation and Topological Rearrangements

This study characterizes liquid-liquid phase coexistence in biomembranes using non-affine deformation and topological rearrangements, identifying ordered and disordered phases without prior lipid knowledge.