A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia
R. A. Voit, L. Tao, F. Yu, L. D. Cato, B. Cohen, X. Liao, C. Fiorini, S. K. Nandakumar, L. Wahlster, K. Teichert, A. Regev, V. G. Sankaran
The paper studies a genetic disorder caused by MECOM haploinsufficiency to identify a transcriptional network critical for HSC maintenance, which is also co-opted in high-risk leukemias.
bioRxiv · Dec 9, 2021Cell Biology