L. Tao

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

SARS-CoV-2 Omicron BA.2.86: less neutralization evasion compared to XBB sub-variants

This study compares the immune evasion of SARS-CoV-2 Omicron BA.2.86 to XBB sub-variants, finding BA.2.86 shows less neutralization evasion.

Neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from ZF2001 RBD-dimer and its next-generation vaccines

This study evaluates the neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from vaccinated individuals and breakthrough infections, finding that next-generation vaccines offer better protection against these variants.

Programming super DNA-enzyme molecules for on-demand enzyme activity modulation

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

RGA1 alleviates low-light-repressed pollen tube growth by improving the metabolism and allocation of sugars and energy

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

The single-cell atlas of the murine reproductive tissues during preterm labor

This study uses scRNA-seq to create a single-cell atlas of murine reproductive tissues during infection-induced preterm labor, identifying gene expression signatures and intercellular communication changes.

Multi-modal Imaging of Disease Progression in TH-MYCN Mouse Models of Neuroblastoma

This study uses multi-modal imaging to compare tumor progression and vascular architecture in TH-MYCN transgenic and implanted neuroblastoma models.

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

The paper studies a genetic disorder caused by MECOM haploinsufficiency to identify a transcriptional network critical for HSC maintenance, which is also co-opted in high-risk leukemias.

Boron Supply Restores Aluminum-Blocked Auxin Transport by Modulation PIN2 Trafficking in the Arabidopsis Roots

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

WY14643 Increases Herpesvirus Replication Independent of PPARα Expression and Inhibits IFNβ Production

This study shows that PPAR agonists like WY14643 increase herpesvirus replication and inhibit IFNβ production, independent of PPARα expression.

Evidence for the Presence of Hyphae and Fruiting Body Calcium Oxalate Crystallites in Schizophyllum commune

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locus

This study generates CCR5-edited T cells and macrophages from nonhuman primate iPSCs, showing resistance to SIV replication.

PAM-interacting domain swapping is extensively utilized in nature to evolve CRISPR-Cas9 nucleases with altered PAM specificities

The paper identifies domain swapping in Cas9 proteins as a mechanism for evolving PAM specificity, demonstrating its prevalence and utility in generating novel PAM-specific enzymes.

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs

The paper examines drug sensitivity variations among C. elegans DEG/ENaC/ASIC channels, showing some are insensitive to amiloride and NSAIDs can inhibit or potentiate them.

Metformin prevented high glucose-induced endothelial reactive oxygen species via OGG1 in an AMPKα-Lin-28 dependent pathway

This study shows metformin reduces high glucose-induced endothelial ROS through the AMPKα-Lin-28-OGG1 pathway in HUVECs and diabetic mice.

Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner

This study shows that IL-4 induces MHV68 reactivation in macrophages but not B cells, indicating cell-type specific regulation of herpesvirus reactivation.

Identification of microbial markers across populations in early detection of colorectal cancer

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

Diversity and biogeography of Woesearchaeota: A comprehensive analysis of multi-environment data

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

Metabolic Control of Viral Infection through PPAR-α Regulation of STING Signaling

This study shows that PPAR-α activation increases herpesvirus replication, suppresses type I interferon, and inhibits STING signaling through ROS.