Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Y. Lei, C. G. Martinez, S. Torres-Odio, S. L. Bell, C. E. Birdwell, J. D. Bryant, C. W. Tong, R. O. Watson, L. C. West, A. P. West
This study shows that type I interferon activation worsens metabolic issues, inflammation, and aging in mice with mitochondrial DNA mutations.
bioRxiv · Sep 22, 2020Immunology