Author

J. D. Bryant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. P. West· 2 shared C. W. Tong· 2 shared L. C. West· 2 shared Y. Lei· 2 shared A. Mohan· 1 shared B. Wang· 1 shared C. E. Birdwell· 1 shared C. G. Martinez· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

A. P. West

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2 papers

Recent·Most cited

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Y. Lei, J. J. Vanportfliet, Y.-F. Chen, J. D. Bryant, Y. Li, D. Fails, S. Torres Odio, K. B. Ragan, J. Deng, A. Mohan, B. Wang, O. Brahms, S. Yates, M. Spencer, C. W. Tong, , A. P. West

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

bioRxiv · May 30, 2022Immunology

Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

Y. Lei, C. G. Martinez, S. Torres-Odio, S. L. Bell, C. E. Birdwell, J. D. Bryant, C. W. Tong, R. O. Watson, L. C. West, A. P. West

This study shows that type I interferon activation worsens metabolic issues, inflammation, and aging in mice with mitochondrial DNA mutations.

bioRxiv · Sep 22, 2020Immunology