Author

L. C. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. P. West· 2 shared C. W. Tong· 2 shared J. D. Bryant· 2 shared Y. Lei· 2 shared A. Mohan· 1 shared B. Wang· 1 shared C. E. Birdwell· 1 shared C. G. Martinez· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. P. West

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Y. Lei, J. J. Vanportfliet, Y.-F. Chen, J. D. Bryant, Y. Li, D. Fails, S. Torres Odio, K. B. Ragan, J. Deng, A. Mohan, B. Wang, O. Brahms, S. Yates, M. Spencer, C. W. Tong, , A. P. West

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

bioRxiv · May 30, 2022Immunology

Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

Y. Lei, C. G. Martinez, S. Torres-Odio, S. L. Bell, C. E. Birdwell, J. D. Bryant, C. W. Tong, R. O. Watson, L. C. West, A. P. West

This study shows that type I interferon activation worsens metabolic issues, inflammation, and aging in mice with mitochondrial DNA mutations.

bioRxiv · Sep 22, 2020Immunology

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

E. Rodrigues, J. Jung, H. Park, C. Loo, S. Soukhtehzari, E. N. Kitova, F. Mozaneh, G. Daskhan, V. Aghanya, S. Sarkar, L. Streith, C. St. Laurent, J.-P. Julien, L. C. West, K. C. Williams, , M. S. Macauley

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

bioRxiv · Jul 28, 2020Biochemistry