SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment
E. Gomez-Abenza, S. Ibanez-Molero, D. Garcia-Moreno, I. Fuentes-Martinez, L. Zon, M. C. Mione, M. L. Cayuela, C. Gabellini, V. Mulero
The paper shows Spint1a deficiency in zebrafish promotes SKCM aggressiveness by enhancing oncogenic transformation, regulating tumor-immune crosstalk, and accelerating metastasis.
bioRxiv · Apr 16, 2019Cancer Biology