V. Mulero

Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation

This study shows that Peds1 deficiency in zebrafish causes myeloid cell apoptosis and worsened inflammation, with plasmalogen supplementation improving outcomes.

Pro-tumor and prothrombotic activities of hepsin in colorectal cancer cells and suppression by venetoclax

This study shows hepsin promotes tumor aggressiveness and thrombosis in colorectal cancer, and venetoclax inhibits these effects by targeting hepsin.

A zebrafish model of COVID-19-associated cytokine storm syndrome reveals that the Spike protein signals via TLR2

This study shows that the S1 domain of SARS-CoV-2 Spike protein induces hyperinflammation in zebrafish larvae via Tlr2/Myd88 signaling, independent of IL-1β, and also triggers emergency myelopoiesis through a Tlr2/Myd88-independent pathway.

Combination therapy targeting inflammasome and fibrogenesis alleviates inflammation and fibrosis in a zebrafish model of silicosis

This study uses a zebrafish model of silicosis to show that combining an inflammasome inhibitor and antifibrotic agent reduces inflammation and fibrosis.

A zebrafish model of COVID-19-associated cytokine storm syndrome reveals differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern.

This paper uses a zebrafish model to study the proinflammatory effects of SARS-CoV-2 Spike proteins from different variants, finding differential inflammatory responses and potential therapeutic targets.

NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos

This study shows that NAMPT-derived NAD+ fuels PARP1 to drive skin inflammation via parthanatos in psoriasis models.

TERT-mediated induction of MIR500A contributes to tumor invasiveness by targeting Hedgehog pathway

The paper shows TERT promotes cancer invasiveness by inducing MIR500A, which suppresses Hedgehog pathway genes.

SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment

The paper shows Spint1a deficiency in zebrafish promotes SKCM aggressiveness by enhancing oncogenic transformation, regulating tumor-immune crosstalk, and accelerating metastasis.

Olfactory sensory neurons mediate ultra-rapid antiviral immune responses in teleosts in a TrkA-dependent manner

This study shows that olfactory sensory neurons in teleosts detect viruses via TrkA receptor interaction, triggering local immune responses and reducing systemic inflammation.