Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation
S. McComb, T. Nguyen, K. A. Henry, D. Bloemberg, D. Bloemberg, A. Marcil, S. Maclean, R. Gilbert, C. Gadoury, R. Pon, T. Sulea, Q. Zhu, R. D. Weeratna
This study shows that truncating the CD8 hinge domain in CARs can finely tune antigen sensitivity, improving selectivity for tumor cells over healthy ones.
bioRxiv · Oct 30, 2020 · PreprintImmunology