T. Nguyen

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in Sorghum and Sugarcane

This paper shows that increasing Rubisco content in sorghum and sugarcane through genetic modification improves photosynthetic efficiency and productivity, with field and greenhouse trials showing biomass increases of 15.5% and 37-81% respectively.

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

This study examines age-associated inflammasome activation in multiple tissues, finding tissue-specific differences in transcriptional and post-translational inflammatory responses.

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo

This study identifies CDC42 inhibitors that reduce vessel branching in both normal skin and tumors, offering potential for treating skin cancer and angiogenesis-related diseases.

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

Reduced cell-substrate adhesion formation promotes cell migration in Dictyostelium

The paper shows that reducing cell-substrate adhesion in Dictyostelium increases migration speed, challenging the conventional focal adhesion model.

The glucocorticoid receptor elicited proliferative response in human erythropoiesis is BCL11A-dependent

The paper shows BCL11A is required for glucocorticoid-induced erythroid expansion in human cells.

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.

This study shows that Centella asiatica extract improves age-related cognitive decline and anxiety in mice, but effects vary by sex, dose, and administration method.

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

Engineered Skin Microbiome Reduces Mosquito Attraction to Mice

This study reduces mosquito attraction to mice by engineering their skin microbiome to lower lactic acid production, offering longer protection than DEET.

Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons

The paper investigates ciliary dynamics in differentiating granule cell neurons, finding that cilia are deconstructed intracellularly and do not reform in adult neurons.

Development of pre-clinical murine models for fibrolamellar hepatocellular carcinoma

This study develops a novel transgenic mouse model of fibrolamellar hepatocellular carcinoma (FLC) and highlights challenges in establishing ex vivo cell models from FLC tumors.

Identification of mouse CD4+ T cell epitopes in SARS-CoV-2 BA.1 spike and nucleocapsid for use in peptide:MHCII tetramers

The paper identifies SARS-CoV-2 BA.1 epitopes recognized by mouse CD4+ T cells and generates corresponding tetramer reagents for studying immune responses.

ADP release can explain spatially-dependent kinesin binding times

This paper identifies ADP release as a rate-limiting factor in kinesin-microtubule binding using experimental data and computational models.

Cross-platform comparison of highly-sensitive immunoassays for inflammatory markers in a COVID-19 cohort

This study compares three immunoassay platforms for inflammatory markers in a COVID-19 cohort, finding differences in detectability, correlation, and differential expression.

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo

This paper introduces a wearable bioelectronic bandage that delivers fluoxetine on-demand to wounds, reducing inflammation and accelerating healing in mice.

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity

This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.

Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish

The paper identifies salmonid-specific proteins in ovarian fluid that enhance egg viability by analyzing proteomic differences and testing biological activity.

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

Massively Concurrent Sub-Cellular Traction Force Videography enabled by Single-Pixel Optical Tracers (SPOTs)

The paper introduces a high-speed, large-field-of-view platform for measuring sub-cellular traction forces in over 10,000 cells at 83 frames per second.

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

This study traces the emergence and spread of Streptococcus suis pathogens in pigs, linking their evolution to changes in farming practices and identifying genomic factors associated with pathogenicity.

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

The paper identifies succinylation of KEAP1 lysine 131 as a mechanism to activate NRF2 transcriptional signaling through metabolic regulation.

Isoform-specific targeting properties of the protocadherin CDHR5 control its apical delivery to promote brush border assembly

This study identifies isoform-specific targeting properties of CDHR5 that drive apical delivery and brush border assembly through interactions with EBP50 and E3KARP.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Quantitative analysis of morphogenesis and growth dynamics in an obligate intracellular bacterium

This paper develops quantitative tools to study the growth and morphology of Rickettsia parkeri, showing MreB is required for its shape and growth.

Phenotypic switch and reduced the growth of melanoma spheroids in the presence of mast cell-conditioned medium: potential impact of nutrient starvation effects

This study investigates how mast cell-conditioned medium affects melanoma spheroid growth and gene expression, suggesting nutrient starvation may explain observed phenotypic changes.

A 96-WELL VALVED MICROFLUIDIC DEVICE FOR TESTING OF LIVE INTACT TUMOR CUBOIDS

The paper introduces a 96-well microfluidic device for testing drug responses in live tumor cuboids, preserving the tumor microenvironment for personalized oncology applications.

In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.