Q. Zhu

Molecular stratification of human fetal vaginal epithelium by spatial transcriptome analysis

This study uses spatial transcriptomics to classify human fetal vaginal epithelium into four zones, identifying distinct gene expression patterns and potential differentiation trajectories.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

Auditory High Entropy Response (A-HER): A Novel Paradigm for Studying Brain Processing of Uncertain Information

The paper introduces A-HER, a paradigm that maximizes auditory stimulus entropy to study brain processing of uncertain information, showing improved signal-to-noise ratio and repeatability compared to other methods.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

An evolutionary optimum amid moderate heritability in prokaryotic cell size

The paper analyzes prokaryotic cell size distribution across 5380 species, finding an optimal size of 0.70 micrometers and moderate heritability.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

The Role of Electron Spin, Chirality, and Charge Dynamics in Promoting thePersistence of Nascent Nucleic Acid-Peptide Complexes

This study shows how chirality and spin enhance protein-DNA complex stability through the chiral-induced spin selectivity effect.

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

HybriSeq: Probe-based Device-free Single-cell RNA Profiling

HybriSeq enables sensitive single-cell RNA profiling by combining in situ hybridization, split-pool barcoding, and sequencing to detect transcripts without end bias.

Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial

The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.

The prevalence of motility within the human oral microbiota

The paper catalogs motile microbes in the human oral microbiota and documents their evolutionary connections through phylogenetic analysis of motility systems.

Effect of Acute Stress on Working Memory in Pilots: Investigating the Modulatory Role of Memory Load

This study examines how acute stress affects working memory in pilots under varying memory loads, finding an interaction where stress may improve accuracy in moderate loads.

HSP90 inhibitor NVP-HSP990 alleviates rotavirus infection

This study shows that NVP-HSP990, a HSP90 inhibitor, effectively reduces rotavirus infection in vitro and in mice by inhibiting replication and alleviating intestinal damage.

Simultaneous CRISPR-Cas9-induced double strand breaks are lethal in models of pancreatic cancer

This study shows CRISPR-Cas9-induced DNA double-strand breaks are more cytotoxic to pancreatic cancer cells than radiation-induced breaks, with significant tumor growth inhibition and chromosomal instability.

Transcription regulation of SARS-CoV-2 receptor ACE2 by Sp1: a potential therapeutic target

This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

This study uses spatial transcriptomics to analyze HCC tumors treated with cabozantinib and nivolumab, identifying distinct immune and fibrotic mechanisms linked to response and recurrence.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT

The paper identifies shared minor histocompatibility antigens (mHAs) that could enhance graft versus leukemia (GvL) effects while minimizing graft versus host disease (GvHD) in allogeneic hematopoietic cell transplants.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The specific roles of renal macrophages in monitoring and clearing off intratubular particles

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

Koisio Technology-Modulated Cell Culture Media can Significantly Increase the Antioxidant Capacity of Mouse Fibroblasts

This study shows that Koisio technology-modulated cell culture media enhance mouse fibroblasts' antioxidant capacity against H2O2-induced stress without adding external substances.

Differential Effects of Koisio Technology-Modulated Solutions on the Growth of Lung Fibroblast Cell Cultures and Lung Cancer Cell Cultures

This study shows Koisio technology-modulated solutions increase lung fibroblast growth by 20% and decrease lung cancer cell growth by 9%, with fibroblasts also showing 14% longer telomeres.

Koisio Technology-Modulated Cell Culture Media can Lead to Markedly Increased Intracellular ATP Levels of Fibroblast Cell Cultures

This study shows that Koisio-modulated cell culture media increases intracellular ATP levels in L929 fibroblasts without affecting mitochondrial membrane potential.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.