GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling
C. Y. Itoh, C. Gunnarson, G. H. Babunovic, A. Nibasumba, N. A. Akilimali, M. H. Wadsworth, T. H. Hughes, S. L. Solomon, B. Hie, B. Berger, A. K. Shalek, S. M. Fortune, B. D. Bryson
This study shows that GM-CSF differentiation of human monocytes reduces IL-10 production through oxidative signaling, highlighting its role in macrophage function and plasticity.
bioRxiv · Sep 29, 2020 · PreprintImmunology