B. D. Bryson

Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

The paper shows that inhibiting Tregs enhances CD8+ T cell priming, improving antitumor responses to 4-1BB combination therapy.

Early cellular mechanism of type I interferon-driven susceptibility to tuberculosis

This study identifies interstitial macrophages and plasmacytoid dendritic cells as key producers of type I IFN during Mtb infection, showing their role in driving tuberculosis pathogenesis through IFN-driven mechanisms.

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

This study identifies Mtb antigens presented on MHC-I and shows that T7SS activity facilitates their presentation.

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas

This study shows MEK inhibition increases MHC-I antigen presentation in melanoma, enhancing immunotherapy efficacy through targeted epitopes.

Biosynthetic Glycan Labeling

This paper develops a chemoselective labeling method for glycans using glycosyltransferase substrates, demonstrating its application to D-arabinofuranose in mycobacteria.

Single-cell analysis reveals the subthreshold TLR response to Mycobacterium tuberculosis infection

This study investigates the subthreshold TLR2 response to Mycobacterium tuberculosis infection and soluble ligands using single-cell analysis in human macrophages.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling

This study shows that GM-CSF differentiation of human monocytes reduces IL-10 production through oxidative signaling, highlighting its role in macrophage function and plasticity.

Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and disease

The paper identifies conserved transcriptional programs in lung mononuclear phagocytes across diseases using a unified framework and applies it to characterize disease-associated populations.

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution

This paper uses single-cell RNA sequencing to identify common and compartment-specific immunological features of severe COVID-19 in lung and blood, finding distinct transcriptional signatures and potential biomarkers like S1PR1.