M. H. Wadsworth

Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of Mycobacterium tuberculosis

Tobacco smoke exposure recruits inflammatory monocytes to the lungs, which support faster Mycobacterium tuberculosis growth.

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

Gene signatures and host-parasite interactions revealed by dual single-cell profiling of Plasmodium vivax liver infection

This study uses single-cell profiling to analyze P. vivax liver infection, identifying host and parasite transcriptional signatures and revealing new insights into parasite dormancy and host responses.

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling

This study shows that GM-CSF differentiation of human monocytes reduces IL-10 production through oxidative signaling, highlighting its role in macrophage function and plasticity.

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.

Identification of a master regulator of differentiation in Toxoplasma

This study identifies BFD1 as a master regulator of differentiation in Toxoplasma gondii through genetic screening and single-cell profiling, showing its necessity and sufficiency for the transition from tachyzoites to bradyzoites.

Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity

This study profiles single-cell RNA-seq data from human respiratory tissues to show reduced epithelial diversity and altered basal progenitor states in type 2 immunity-driven diseases.