Author

C. H. Bohrer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Xiao· 4 shared B. Ross· 2 shared B. Tenner· 2 shared E. Roberts· 2 shared J. Zhang· 2 shared M. Lakadamyali· 2 shared A. Arab· 1 shared A. N. Santiago-Ruiz· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

J. Xiao

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Author profile →

5 papers

Recent·Most cited

Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes

C. H. Bohrer, D. R. Larson

The paper uses single-cell imaging methods to show that physical distance, not genomic distance, drives co-bursting of gene transcription in human chromosomes.

bioRxiv · Jul 7, 2022Biophysics

A spatial stochastic model reveals the role of supercoiling in transcription regulation

Y. Geng, C. H. Bohrer, N. Yehya, H. Hendrix, L. Shachaf, J. Liu, J. Xiao, E. Roberts

This paper develops a spatial stochastic model to show how supercoiling affects transcription regulation in E. coli by enabling communication between RNA polymerase molecules and coordinating gene expression.

bioRxiv · Dec 29, 2021Biophysics

Tau forms oligomeric complexes on microtubules that are distinct from pathological oligomers in disease

M. T. Gyparaki, A. Arab, E. M. Sorokina, A. N. Santiago-Ruiz, C. H. Bohrer, J. Xiao, M. Lakadamyali

The paper uses SMLM to show physiological tau oligomers on microtubules differ from pathological oligomers and links phosphorylation states to aggregate species.

bioRxiv · Jul 7, 2020 · PreprintCell Biology

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

B. Tenner, M. Getz, B. Ross, D. Ohadi, C. H. Bohrer, E. Greenwald, S. Mehta, J. Xiao, P. Rangamani, J. Zhang

The paper shows that spatially distinct cAMP oscillations, in-phase with Ca2+ and out-of-phase with PKA, regulate signaling in pancreatic β cells through nanodomain clustering of adenylyl cyclases and phosphodiesterases.

bioRxiv · Jan 10, 2020Cell Biology

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

C. H. Bohrer, X. Yang, X. Weng, B. Tenner, S. Thakur, R. McQuillen, B. Ross, M. Wooten, X. Chen, M. Lakadamyali, J. Zhang, E. Roberts, J. Xiao

The paper introduces DDC, a method to correct blinking artifacts in SMLM by using true pairwise distance distributions, improving spatial reconstruction accuracy.

bioRxiv · Jan 2, 2020 · PreprintBiophysics