S. Thakur

Guava cv. Allahabad Safeda Chromosome scale assembly and comparative genomics decodes breeder choice marker trait association for pink pulp colour

The paper presents a chromosome-scale guava genome assembly and identifies a gene associated with pink pulp color through comparative genomics and marker-trait association analysis.

Shear flow as a tool to distinguish microscopic activities of molecular machines in a chromatin loop

The paper uses shear flow to differentiate between two types of molecular machine activities in chromatin loops through simulation analysis.

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.

Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina

This study characterizes antimicrobial resistance in E. coli from retail meat in North Carolina, finding higher prevalence and MDR in turkey isolates, with no link between antibiotic use claims and MDR.

Recurrent evolution of small body size and loss of the sword ornament in Northern Swordtail fish

The paper uses whole-genome sequencing to resolve phylogenetic relationships in Xiphophorus fish, revealing recurrent loss of sexually selected traits like body size and sword ornaments.

Uncovering Changes in Microbiome Profiles Across Commercial and Backyard Poultry Farming Systems

This study compares microbiome profiles between commercial and backyard poultry farming systems over time, finding significant differences in diversity and taxa abundance.

Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding

This study models SARS-CoV-2 spike-protein mutations' effects on ACE2 binding using computational methods, showing major variants maintain affinity better than random mutations.

Ultra-accurate Microbial Amplicon Sequencing with Synthetic Long Reads

This paper introduces LoopSeq, a synthetic long-read sequencing technology that improves accuracy and length for microbial identification, enabling species and strain-level analysis from complex samples.

Genomic screening of antimicrobial resistance markers in UK and US Campylobacter isolates highlights stability of resistance over an 18 year period

This study analyzes AMR markers in Campylobacter isolates from the UK and US between 2001-2018, finding stable resistance prevalence despite reduced antibiotic use.

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.

Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish

This study identifies oca2 as a gene with pleiotropic effects that contributes to both albinism and sleep loss in cavefish.

ORP1L regulates dynein clustering on endolysosmal membranes in response to cholesterol levels

This study shows ORP1L regulates dynein clustering on endolysosomal membranes in response to cholesterol levels, affecting endolysosome positioning.

Identification of PCNA interacting protein motifs in human DNA polymerase delta

The paper identifies a non-canonical PIP box in human DNA polymerase delta p125 that binds PCNA, contributing to its processive replication function.

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

The paper introduces DDC, a method to correct blinking artifacts in SMLM by using true pairwise distance distributions, improving spatial reconstruction accuracy.

Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation.

This study analyzes the population genomics of Vibrionaceae bacteria from an endangered oasis, finding evidence of local adaptation and closed pan-genomes despite environmental perturbation.

International lineages of Salmonella enterica serovars isolated from chicken farms, Wakiso District, Uganda

The study examines MDR Salmonella in Ugandan chicken farms, identifying resistance patterns and plasmid replicons, highlighting the need for surveillance.