Author

C. J. Houldcroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. G. Pedersen· 1 shared A. Margaryan· 1 shared E. Pavlova· 1 shared E. Y. Lim· 1 shared F. Balloux· 1 shared G. Okecha· 1 shared L. van Dorp· 1 shared L. Vinner· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

A. G. Pedersen

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2 papers

Recent·Most cited

Antiviral activity of Cytomegalovirus-specific CD4+ T cells against lytically infected non-haemopoietic cells

E. Y. Lim, C. J. Houldcroft, S. E. Jackson, G. Okecha, M. R. Wills

This study demonstrates that HCMV-specific CD4+ T cells can prevent viral dissemination in fibroblasts and that IFN-γ is a key antiviral cytokine in their secretome.

bioRxiv · Dec 8, 2022 · PreprintImmunology

31,600-year-old human virus genomes support a Pleistocene origin for common childhood infections

S. Holtsmark Nielsen, L. van Dorp, C. J. Houldcroft, A. G. Pedersen, M. E. Allentoft, L. Vinner, A. Margaryan, E. Pavlova, V. Chasnyk, P. Nikolskiy, V. Pitulko, V. N. Pimenoff, F. Balloux, M. Sikora

The paper analyzes ancient virus genomes from 31,600-year-old human remains, showing that common childhood infections originated in the Pleistocene.

bioRxiv · Jun 28, 2021 · PreprintEvolutionary Biology