Author

C. J. McCann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:spatial domain detection· 1

Frequent Co-Authors

J. M. Kelly· 3 shared M. C. Taylor· 3 shared M. D. Lewis· 3 shared A. A. Khan· 2 shared A. F. Francisco· 2 shared H. C. Langston· 2 shared S. Jayawardhana· 2 shared A. I. Ward· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

J. M. Kelly

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

A. A. Khan, H. C. Langston, L. Walsh, R. Roscoe, S. Jayawardhana, A. F. Francisco, M. C. Taylor, C. J. McCann, J. M. Kelly, M. D. Lewis

This study shows that curative treatment with benznidazole at 6 weeks post-infection reverses digestive Chagas disease symptoms in mice, while delayed treatment leads to irreversible damage.

bioRxiv · Dec 14, 2022Microbiology

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

A. A. Khan, H. C. Langston, F. C. Costa, F. Olmo, M. C. Taylor, C. J. McCann, J. M. Kelly, M. D. Lewis

The paper identifies chronic T. cruzi infection foci in the colon linked to enteric neuropathic lesions, suggesting chemotherapy could prevent chronic disease.

bioRxiv · Mar 9, 2021Microbiology

In vivo analysis of Trypanosoma cruzi persistence foci at single cell resolution

A. I. Ward, M. D. Lewis, A. Khan, C. J. McCann, A. F. Francisco, S. Jayawardhana, M. C. Taylor, J. M. Kelly

This study identifies skeletal muscle and skin as major sites of Trypanosoma cruzi persistence in chronic murine infections using high-sensitivity imaging.

mBio · Aug 25, 2020Peer-reviewedMicrobiology

Dynamic integration of enteric neural stem cells in ex vivo organotypic colon cultures.

G. Navoly, C. J. McCann

This study shows donor enteric neural stem cells integrate into colonic tissue through dynamic migration and ECM remodeling in an ex vivo culture system over three weeks.

bioRxiv · Jun 12, 2020Cell Biology