H. C. Langston

A panel of phenotypically and genotypically diverse bioluminescent: fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research

The paper describes a panel of bioluminescent and fluorescent Trypanosoma cruzi strains to study Chagas disease, enabling real-time monitoring of infection dynamics and drug screening.

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

This study shows that curative treatment with benznidazole at 6 weeks post-infection reverses digestive Chagas disease symptoms in mice, while delayed treatment leads to irreversible damage.

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

The paper identifies chronic T. cruzi infection foci in the colon linked to enteric neuropathic lesions, suggesting chemotherapy could prevent chronic disease.