Author

C. J. Merrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:plant (other)· 7 Research Focus:cell type annotation· 4 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

F. I. G. Totanes· 3 shared C. K. Kwok· 2 shared F. Dumetz· 2 shared J. McDonald· 2 shared A. J. Enright· 1 shared A. Jensen· 1 shared A. L. Jensen· 1 shared A. M. Blagborough· 1 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

F. I. G. Totanes

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8 papers

Recent·Most cited

Effects of the G-quadruplex-binding drugs Quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum

H. M. Craven, G. Nettesheim, P. Cicuta, A. M. Blagborough, C. J. Merrick

This study investigates the effects of G-quadruplex-binding drugs quarfloxin and CX-5461 on Plasmodium falciparum, showing differing mechanisms of action and antimalarial efficacy.

bioRxiv · Jul 13, 2023 · PreprintMicrobiology

Histone lactylation: A new epigenetic axis for host-parasite signalling in malaria?

C. J. Merrick

This paper explores histone lactylation in malaria parasites, suggesting it may regulate virulence and gene expression in response to host lactate levels.

bioRxiv · Sep 22, 2022Microbiology

Replication origin mapping in the malaria parasite Plasmodium falciparum

F. I. G. Totanes, J. Gockel, S. E. Chapman, R. Bartfai, M. A. Boemo, C. J. Merrick

This study maps replication origins in Plasmodium falciparum using DNAscent technology, finding that origin activation is less dense and preferentially occurs in low transcriptional activity regions.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi

J. McDonald, C. J. Merrick

This study compares DNA replication dynamics during schizogony in Plasmodium falciparum and Plasmodium knowlesi, finding differences in gap phases and replication efficiency between the species.

bioRxiv · Dec 20, 2021Microbiology

Dynamics of DNA replication during male gametogenesis in the malaria parasite Plasmodium falciparum

H. Matthews, J. McDonald, F. I. G. Totanes, C. J. Merrick

The paper tracks DNA replication dynamics during male gametogenesis in Plasmodium falciparum, revealing unique features like no pre-gametogenesis replication, absence of karyokinesis between replication rounds, uncoupled cytokinesis, and distinct single-molecule replication dynamics.

bioRxiv · Dec 18, 2021Microbiology

Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA

J. Edwards-Smallbone, A. L. Jensen, L. E. Roberts, F. I. G. Totanes, S. R. Hart, C. J. Merrick

This study identifies PfGBP2 in Plasmodium falciparum as a telomere-associated protein that binds G-quadruplex DNA and RNA, suggesting potential as an anti-malarial target.

bioRxiv · Jul 2, 2021Microbiology

The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/T-rich transcriptome

F. Dumetz, A. J. Enright, J. Zhao, C. K. Kwok, C. J. Merrick

This study characterizes the in vivo RNA structurome of Plasmodium falciparum, revealing structural features that influence translation and decay, and comparing it to a balanced species.

bioRxiv · Apr 29, 2021Microbiology

G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum

F. Dumetz, E. Y.-C. Chow, L. M. Harris, M. I. Umar, A. Jensen, B. Chung, T. F. Chan, C. J. Merrick, C. K. Kwok

This study identifies RNA G-quadruplexes in Plasmodium falciparum and shows they influence translation of specific genes, including virulence factors.

bioRxiv · Mar 8, 2021Microbiology