J. McDonald

CLSTN3B enhances adipocyte lipid droplet structure and function via endoplasmic reticulum contact

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

A standard protocol to report discrete stage-structured demographic information

The paper identifies issues in reporting matrix population models (MPMs) and introduces a standardized protocol to improve reproducibility and clarity in their presentation.

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3

This study shows statins reduce macrophage cholesterol, upregulate JMJD3, and shift macrophage activation toward anti-inflammatory responses in both M1 and M2 states.

Reducing Cholesterol in Resting Macrophage Activates NF-kB through Mitochondria, Resulting in Epigenomic Reprogramming to Dampen Inflammation in Activated Macrophages

DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi

This study compares DNA replication dynamics during schizogony in Plasmodium falciparum and Plasmodium knowlesi, finding differences in gap phases and replication efficiency between the species.

Dynamics of DNA replication during male gametogenesis in the malaria parasite Plasmodium falciparum

The paper tracks DNA replication dynamics during male gametogenesis in Plasmodium falciparum, revealing unique features like no pre-gametogenesis replication, absence of karyokinesis between replication rounds, uncoupled cytokinesis, and distinct single-molecule replication dynamics.

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

This study compares high-volume and high-load resistance training on muscle growth and molecular markers, finding similar hypertrophic and strength adaptations despite differences in protein synthesis rates.

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

This study identifies FASN as a therapeutic target in KRAS-mutant lung cancer by showing its role in lipid metabolism and ferroptosis induction.

The association of child maltreatment and systemic inflammation in adulthood: A systematic review

This paper reviews the association between child maltreatment and systemic inflammation in adults, finding mixed results and highlighting methodological issues.

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

The paper shows that two forms of Opa1 work together to regulate mitochondrial inner-membrane fusion, with l-Opa1 enabling docking and s-Opa1 facilitating efficient pore opening.

Ndc80/Nuf2-like protein KKIP1 connects a stable kinetoplastid outer kinetochore complex to the inner kinetochore and responds to metaphase tension

This study identifies a stable 9-protein kinetoplastid outer kinetochore complex linked to the inner kinetochore via KKIP1, which responds to metaphase tension through elongation.

The hunger games: sensing host arginine is essential for Leishmania parasite virulence

This study shows that Leishmania parasites use an arginine sensing mechanism to enhance virulence by up-regulating arginine transport during infection.

Unbiased analysis of C. elegans behavior reveals the use of distinct turning strategies during magneticorientation

This study identifies two distinct turning strategies in C. elegans for magnetic orientation, contrasting with strategies for graded stimuli.

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells

This study identifies Rap1a as a conserved regulator of glioblastoma cancer stem cell migration using a combination of Drosophila and human models.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.