Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude
J. Ju, H. N. Lee, L. Ning, H. Ryu, X. X. Zhou, H. Chun, Y. W. Lee, A. I. Lee-Richerson, C. Jeong, M. Lin, J. Seong
The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.
bioRxiv · Feb 5, 2021Bioengineering