Author

H. Chun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. C. Gomes· 1 shared A. I. Lee-Richerson· 1 shared A. Korde· 1 shared B. Clark· 1 shared B. Hu· 1 shared C. Jeong· 1 shared D. Bang· 1 shared D. Muscato· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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1 shared paperImmunology

A. C. Gomes

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5 papers

Recent·Most cited

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

Z. Harris, A. Korde, J. Khoury, E. Manning, G. Stanley, K. Mitchell, Y. Sun, B. Hu, H. J. Shin, J. Joerns, B. Clark, L. Placek, D. Unutmaz, H. Chun, L. Sharma, , J. Koff

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

bioRxiv · May 24, 2024Cell Biology

Myospreader improves gene editing in skeletal muscle by myonuclear propagation

K. Poukalov, M. C. Valero, D. Muscato, L. Adams, H. Chun, Y. i. T. Lee, N. Andrade, Z. Zeier, H. L. Sweeney, E. T. Wang

Myospreader enhances CRISPR/Cas9 gene editing in skeletal muscle by promoting myonuclear propagation and improving therapeutic efficacy in mouse models.

bioRxiv · Nov 6, 2023Cell Biology

Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size.

R. Miao, H. Chun, A. C. Gomes, J. Choi, J. Pereira

The paper shows that competition between hematopoietic stem cells and progenitors regulates HSC compartment size through mSCF availability.

bioRxiv · Dec 12, 2021Immunology

Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

J. Ju, H. N. Lee, L. Ning, H. Ryu, X. X. Zhou, H. Chun, Y. W. Lee, A. I. Lee-Richerson, C. Jeong, M. Lin, J. Seong

The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.

bioRxiv · Feb 5, 2021Bioengineering

Single-cell analysis of a mutant library generated using CRISPR-guided deaminase

S. Jun, H. Lim, H. Chun, J. H. Lee, D. Bang

The paper develops a CRISPR-based platform combining deaminase and scRNA-seq to introduce and assess substitution mutations, enabling high-throughput analysis of mutation-associated transcriptional effects.

bioRxiv · Jan 21, 2020Bioengineering