Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in Outcomes
A. R. Ouellette, N. Hadad, A. Deighan, L. Robinson, K. M. S. O'Connell, A. Freund, G. A. Churchill, C. Kaczorowski
This study finds that long-term dietary restrictions like caloric restriction or fasting do not improve cognitive performance in genetically diverse mice and may even be harmful, with genetic factors playing a key role in memory outcomes.
bioRxiv · Apr 9, 2022Animal Behavior & Cognition