M. Kaeberlein

An anti-depressant drug vortioxetine suppresses malignant glioblastoma cell growth.

This study investigates vortioxetine's anti-cancer effects on glioblastoma cells using cell viability and migration assays, showing suppression of cell growth and survival.

The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience

The paper reanalyzes lifespan studies and finds that short-lived controls overestimate intervention efficacy, proposing a 900-day rule to assess confidence in longevity interventions.

Preservation of Mitochondrial Membrane Potential is Necessary for Lifespan Extension from Dietary Restriction

This study shows that preserving mitochondrial membrane potential during dietary restriction extends lifespan in C. elegans by maintaining mitochondrial function and nutrient sensing.

Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan

The paper demonstrates that increasing mitochondrial membrane potential in C. elegans using a light-activated proton pump extends lifespan and reverses age-related phenotypes.

Evidence that conserved essential genes are enriched for pro-longevity factors

The paper shows that overexpressing conserved essential genes in yeast increases replicative lifespan more than deleting them, suggesting essential genes are important for longevity.

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

Once-daily feeding is associated with better health in companion dogs: Results from the Dog Aging Project

The paper investigates the association between once-daily feeding and better health in companion dogs using data from the Dog Aging Project.

Pharmacokinetics of long-term low-dose oral rapamycin in four healthy middle-aged companion dogs

This study measures rapamycin blood concentrations and pharmacokinetics in dogs on long-term low-dose oral administration.

Rapamycin rejuvenates oral health in aging mice

Short-term rapamycin treatment reverses periodontal bone loss, reduces inflammation, and shifts the oral microbiome to a more youthful state in aged mice.

A physicochemical roadmap of yeast replicative aging

This study measures physicochemical changes in yeast cells during replicative aging, finding acidification and organellar crowding contribute to homeostatic decline.

Isolation and characterization of extracellular vesicles from Caenorhabditis elegans for multi-omic analysis.

This paper isolates and characterizes extracellular vesicles from C. elegans, showing they share key properties with mammalian EVs and enabling multi-omic analysis.

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

This study shows that ageing mitotic cells experience reduced NPC component abundance and misassembled NPCs, leading to decreased nuclear transport and increased compartmentalization.