Author

J. S. McLean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

W. Shi· 3 shared X. He· 3 shared B. Bor· 2 shared L. Cen· 2 shared A. Kang· 1 shared A. Liu· 1 shared A. Ouellette· 1 shared B. Batbileg· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

W. Shi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Episymbiotic bacterium induces intracellular lipid droplet production in its host bacteria

P.-T. Dong, J. Tian, K. J. Kobayashi-Kirschvink, L. Cen, J. S. McLean, B. Bor, W. Shi, X. He

This study investigates the interaction between Saccharibacteria TM7x and its host XH001, revealing TM7x-induced lipid droplet formation in XH001 and its protective role under stress.

bioRxiv · Sep 6, 2023 · PreprintMicrobiology

Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter

Y. Wang, L. A. Gallagher, P. A. Andrade, A. Liu, I. R. Humphreys, S. Turkarslan, K. J. Cutler, M. L. Arrieta-Ortiz, Y. Li, M. C. Radey, J. S. McLean, Q. Cong, D. Baker, N. S. Baliga, S. B. Peterson, J. D. Mougous

The paper genetically manipulates Saccharibacteria from the CPR to study their role in epibiotic growth and develops bioinformatic resources for their analysis.

bioRxiv · May 2, 2023Microbiology

Transcriptome of epibiont Saccharibacteria Nanosynbacter lyticus strain TM7x during establishment of symbiosis

E. L. Hendrickson, B. Batbileg, K. A. Kristopher, E. I. Lamont, L. Cen, Y. Chang, J. Liu, W. Shi, X. He, J. S. McLean

This study examines gene expression changes in Saccharibacteria TM7x and its host during symbiosis establishment, revealing dynamic interactions and functional roles in maintaining the relationship.

bioRxiv · Mar 25, 2022Microbiology

Evidence of independent acquisition and adaption of ultra-small bacteria to human hosts across the highly diverse yet reduced genomes of the phylum Saccharibacteria

J. S. McLean, B. Bor, T. T. To, Q. Liu, K. A. Kearns, L. M. Solden, K. C. Wrighton, X. He, W. Shi

This study captures novel genomes from Saccharibacteria groups in humans and mammals, revealing convergent evolution and independent adaptation to human hosts.

Cell Reports · Jul 1, 2020Peer-reviewedMicrobiology

Rapamycin rejuvenates oral health in aging mice

J. Y. An, K. A. Kerns, A. Ouellette, L. Robinson, D. Morris, C. Kaczorowski, S.-I. Park, T. Mekvanich, A. Kang, J. S. McLean, T. Cox, M. Kaeberlein

Short-term rapamycin treatment reverses periodontal bone loss, reduces inflammation, and shifts the oral microbiome to a more youthful state in aged mice.

bioRxiv · Dec 10, 2019Pathology