Metformin preconditioning protects against myocardial stunning and preserves mitochondrial dynamics and protein translation in a mouse model of cardiac arrest
C. Rutledge, C. Lagranha, T. Chiba, K. Redding, D. Stolz, E. Goetzman, S. Sims-Lucas, B. A. Kaufman
This study shows metformin pretreatment protects against cardiac and renal damage after cardiac arrest in mice through AMPK activation, preserving protein translation and mitochondrial function.
bioRxiv · Aug 24, 2021 · PreprintPhysiology