B. A. Kaufman

Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19

This study shows that maternal extracellular vesicles from COVID-19 pregnancies alter trophoblast function, contributing to placental dysfunction.

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

Extracellular release of mitochondrial DNA is triggered by cigarette smoke and is detected in COPD

This study shows that cigarette smoke triggers mitochondrial DNA release in COPD patients and animal models, linking it to inflammation and disease progression.

Metformin preconditioning protects against myocardial stunning and preserves mitochondrial dynamics and protein translation in a mouse model of cardiac arrest

This study shows metformin pretreatment protects against cardiac and renal damage after cardiac arrest in mice through AMPK activation, preserving protein translation and mitochondrial function.

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.

A novel ultrasound-guided mouse model of sudden cardiac arrest

This paper develops an ultrasound-guided method to induce sudden cardiac arrest in mice, showing rapid asystole and reliable survival rates with secondary organ damage but no neurologic dysfunction.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.